Although Hirotaka et al. found that dietary consumption of Lactobacillus-derived exopolysaccharide induced CCR6+ CD8+ T cells by CCL20-secreting tumor cells [56], Wang et al. also uncovered FOXO1 promoted the migration of M2 macrophages via CCL20 secretion in esophageal squamous cell carcinoma [57]. This evidence concerns the gene CD8A and esophageal squamous cell carcinoma.