E-cadherin is a canonical epithelial hallmark, and loss of E-cadherin expression is a hallmark of EMT.42,43 We then tested both the E-cadherin level and SYK level in 102 NSCLC specimens by IHC to explore whether high SYK expression was associated with the epithelial phenotype in patient samples. This evidence concerns the gene SYK and non-small cell lung carcinoma.