WNT2 secreted by tumor cells or cancer-associated fibroblasts inhibits DC-mediated antitumor T cell responses via the SOCS3/p-JAK2/p-STAT3 signaling cascade, promoting the malignant progression of solid tumors including colorectal cancer, esophageal squamous cell carcinoma, gastric cancer, and breast cancer [248–251]. This evidence concerns the gene STAT3 and cancer.