Since GCTs are histologically diverse, the treatment choice primarily depends on the tumor’s histology and tumor markers, such as α-1-fetoprotein (AFP) and beta human chorionic gonadotropin (bHCG).2 In extracranial GCTs, treatment options vary between surgical resection/biopsy followed by observation or chemotherapy, depending on the histology and degree of resection. This evidence concerns the gene AFP and neoplasm.