LIPA and hydrops fetalis: Whereas chow diet-fed global LAL KO mice exhibited decreased body weight and increased plasma cholesterol levels [34], iLAL KO mice had comparable body weight (Figure 2A) and plasma lipid parameters to their control littermates (Figure 2B) when fed chow (Figure 2A,B) or HF/HCD (Supplementary Figs. S1A and B).