Given the massive increase in Trem2 gene and protein expression (Figure 5A,E), we finally assessed whether these macrophages were comparable to the recently described macrophage subclass of lipid-associated macrophages (LAMs), which have been attributed a preventive role against systemic hypercholesterolemia and adipocyte hypertrophy [43]. Here, TREM2 is linked to Hypercholesterolemia.