Whilst inflammatory markers such as INF-α, CRP and IL-6 have been implicated in the interaction between inflammation and glutamate in depression (Felger et al., 2016; Haroon et al., 2014; Hashimoto, 2015; Ho et al., 2021; Walker et al., 2015), our main finding was a relationship between INF-γ and brain glutamate across the whole patient cohort, which could potentially suggest some degree of specificity to schizophrenia. Here, IL6 is linked to depressive disorder.