FOXI1 and neoplasm: ,16 Of note, our single-cell transcriptome analysis has uncovered transcriptomic intra-tumour heterogeneity in BHD-associated HOCT, comprised of two distinct cell clusters of L1CAM expressing cells and FOXI1 expressing cells in which expression patterns of Notch signalling-associated genes were different, suggesting that expression patterns of L1CAM and FOXI1 determined by Notch signalling may associate with diverse molecular characteristics of renal tumours (Fig. 2c) (Supplementary Fig. S1a).17