FLCN and chromophobe renal cell carcinoma: ,11 BHD-associated renal tumourigenesis is triggered by biallelic loss of the FLCN gene, whereas sporadic ChRCC frequently harbors tumour protein p53 (TP53) and/or phosphatase and tensin homolog (PTEN) alterations without FLCN alteration and in classical types generally has copy loss of chromosomes 1, 2, 6, 10, 13 and 17.1