,11 BHD-associated renal tumourigenesis is triggered by biallelic loss of the FLCN gene, whereas sporadic ChRCC frequently harbors tumour protein p53 (TP53) and/or phosphatase and tensin homolog (PTEN) alterations without FLCN alteration and in classical types generally has copy loss of chromosomes 1, 2, 6, 10, 13 and 17.1 The gene discussed is PTEN; the disease is chromophobe renal cell carcinoma.