However, some of the signatures were different between these tumours, including SBS1 (Spontaneous deamination of 5-methylcytosine, clock-like signature), SBS2 (APOBEC activity), SBS5 (Unknown, clock-like signature), SBS13 (APOBEC activity), insertions and deletions (ID)2 (Slippage during DNA replication of the template DNA strand) and ID8 (DBS repair by non-homologous end-joining), highlighting molecular differences of these tumours. Here, CLOCK is linked to neoplasm.