*1,834 proteins identified*356 proteins showed ≥2-fold change, out of which 198 upregulated and 158 downregulated*Out of 356 differentially expressed proteins, 56% were membrane localized*Overexpression of EGFR CHI3L1, XRCC6, GOLIM4, SCARB2, ATL3 in GBM in GBM*EPB41L3, PALM2, NEGR1 were downregulated*Top three pathways: acute-phase response signaling, caveolar signaling, and calcium signaling were associated with cancer progression. This evidence concerns the gene XRCC6 and cancer.