Lipid nanoparticles have been employed to transport a small molecule inhibitor of macrophage colony-stimulating factor 1 receptor (CSF1R) signaling, in conjunction with signal-regulatory protein-α (SIRPα) blocking antibodies, for the purpose of reprogramming tumor-associated macrophages (TAMs) from an immunosuppressive state to a tumoricidal state in both murine and human xenograft tumor models (42). This evidence concerns the gene SIRPA and neoplasm.