At the same time, they also found that depletion of ENTR1 in HCT116, a CRC cell line, could activate caspase 8 and caspase 3 mediated apoptosis and the level of intracellular ENTR1 was regulated by caspases 6 and caspase 8 (41). This evidence concerns the gene CASP6 and colorectal carcinoma.