HLA-C and cancer: Antigen-presenting cells (APCs) including dendritic cells (DCs) and macrophages present antigenic peptides of cancer cells to T cells, the peptide binding major histocompatibility complex molecules (MHCs) is exposed on the cell surface to be recognized by T cell receptors (TCRs) and form TCR-peptide-MHC complex that activates the T cell (83).