Some subtypes of PTCLs, especially those with a follicular helper T-cell (TFH) phenotype, can share similar morphology and immunophenotype, including a complex inflammatory background of cell proliferation and Hodgkin/Reed-Sternberg (HRS) cells that present features of CHL phenotypes such as CD30 positivity, PAX5 weak positivity, CD45 negativity, and EBER positivity, leading to a misdiagnosis between them (31–34). The gene discussed is PAX5; the disease is classic Hodgkin lymphoma.