METTL16 and pachyonychia congenita: The results showed that the level of METTL16 in PDAC tissues was significantly lower than that in paired paracancerous nontumor tissues (Figure 1A), and the mRNA expression level of METTL16 was relatively higher in patients with a relatively low PC stage (I-II) than in those with a high PC stage (III-IV) (Figure 1B).