CD28 and angioimmunoblastic T-cell lymphoma: Recent studies involving NGS techniques have demonstrated variable proportions of recurrent mutations involving the RhoA GTPase, epigenetic regulatory genes (IDH-2, TET-2 and DNMT3A) and genes involved in the TCR signaling pathway (PLCγ, CD28, FYN and VAV-1) in patients with AITL (99, 100).