DNMT3A and angioimmunoblastic T-cell lymphoma: Concerning to molecular aspects, AITL is characterized by the presence of recurrent mutations involving the RhoA gene and epigenetic regulatory genes, implicated in the processes of DNA-methylation, histone-deacetylation, and regulation of nuclear chromatin remodeling, such as IDH-2, DNMT3A and TET-2 (3).