Following this multi-step process, specific mutations such as RhoA G17V/IDH-2, NPM-1 and NOTCH-1 will predispose to the emergence and expansion of malignant clones of AITL, CMML and DLBCL, respectively, all of them considered as correlated hematopoietic neoplasms (46, 72–74). This evidence concerns the gene IDH2 and angioimmunoblastic T-cell lymphoma.