A study showed that a few key players (e.g. retinoic acid receptor β (RARβ), peroxisome proliferator-activated receptor β and δ (PPARβ/δ), vitamin D receptor (VDR), glucocorticoid receptor (GR) and androgen receptor (AR) in the context of skin cancer) seem to be involved in both cancer aggressiveness and drug resistance. The gene discussed is NR3C1; the disease is skin cancer.