Despite there are no reports on the role of Neurabin-1 in carcinogenesis, the loss of Neurabin-2 (also known as Spinophilin or PPP1R9B), which has 80% homology in its sequence and similar biological functions to Neurabin-1, was associated with more aggressive histological phenotype, faster relapse, poor survival, and a low response to fluoropyrimidine-based chemotherapy in CRC (78, 79). This evidence concerns the gene PPP1R9B and colorectal carcinoma.