In squamous cell carcinoma of the head and neck (HNSCC), after the treatment of cisplatin, ΔNp63 is phosphorylated at S385G (p-ΔNp63S385G) by ATM and degraded following DNA damage (104); then, ΔNp63 also downregulates the expression of mir-181a, mir-519a, and mir-374a, leading to a series of mRNAs involved in apoptosis, rendering cancer cells more sensitive to DNA damage agents (Figure 4) (75, 107, 108). This evidence concerns the gene ATM and head and neck squamous cell carcinoma.