EGFR and cancer: In addition, ΔNp63 also triggers a variety of survival signaling cascades, for example, the epithelial growth factor receptor (EGFR), transforming growth factor (TGFβ), and hepatocyte growth factor receptor (HGFR) pathways to drive tumor invasiveness and metastasis (79–82), and activate a set of DNA damage repair-related genes [such as CDK12 (83) and SMG1 (84) proteins], thus promoting cancer cell survival and proliferation.