IRF6 and nonpapillary renal cell carcinoma: The result in the GEO dataset showed that the expression levels of IRF1/2/3/4/5/7/8/9 in ccRCC samples were significantly upregulated compared with those in the normal samples, whereas the expression level of IRF6 in ccRCC samples was significantly downregulated compared with that in the normal samples (Figure 1B).