We also found that IRF1, IRF3, IRF4, IRF5 and IRF7 were significantly higher in tumor stage III/IV or grade 3/4 compared with tumor stage I/II or grade 1/2, whereas the expression level of IRF6 was lower in tumor stage III/IV or grade 3/4 (Supplementary Figure S4). The gene discussed is IRF1; the disease is neoplasm.