Based on the TCGA-KIRC dataset, the mRNA expression levels of IRF1/2/3/4/5/7/8/9 in 539 ccRCC samples were significantly higher than those in 72 normal samples, whereas the mRNA expression level of IRF6 in 539 ccRCC samples was significantly lower than that in 72 normal samples (Figure 1A). The gene discussed is IRF1; the disease is nonpapillary renal cell carcinoma.