CHEK2 and breast carcinoma: The genes we sequenced belong mainly to the DNA Interstrand Crosslink Repair, a DDR pathway that has been recently associated which high tumor burden in breast carcinomas (22); the rest were DNA damage sensors (ATM, CHK2) and transcriptional activators (ARID1A, TP53) that had been recently associated with metastatic breast cancer (23–25).