Moreover, MIR-150 is downregulated and matrix metalloproteinase 14 (MMP14) while vascular endothelial growth factor (VEGF) are upregulated in RA, and mesenchymal stem cell derived miR-150 exosomes inhibit RA fibroblast-like synoviocytes migration and invasion, as well as suppressing angiogenesis by downregulation of MMP14 and VEGF, as a result, the symptoms of RA alleviate (107). This evidence concerns the gene VEGFA and rheumatoid arthritis.