CD5 and B-cell chronic lymphocytic leukemia: However, miR-150 was found upregulated in CLL in both CD5- and CD5+ B cells and in 70kDa zeta chain-related protein-positive and IgVH mutated patients in certain cases (11, 59, 86), and it plays a critical role in the hematopoiesis process, especially in the differentiation and development of lymphoid lineage (8).