MIR-150 is downregulated in several B-lymphocyte malignancies (49, 54–57), such as diffuse large B-cell lymphoma (DLBCL) (55), mantle cell lymphoma (MCL) (54), BL (9) and aggressive chronic lymphocytic leukemia (CLL) (11). The gene discussed is MIR150; the disease is B-cell chronic lymphocytic leukemia.