With our model we were able to obtain good fits if the exhausted state was correlated with HAVCR2 or LAG3 but not with PDCD1/CD274, which was due to the early peak of Pdcd1 and Cd274 transcription that was already well in decline on day 5 while CTL numbers in the tumor remained high. The gene discussed is HAVCR2; the disease is neoplasm.