In contrast to HAVCR2 and LAG3, the dynamics of PDCD1 and CD274 did not coincide with the dynamics of CTL exhaustion, suggesting a relatively minor role for PD-1/PD-L1 as determinants of CTL exhaustion in the B16F10 melanoma model, at least at late stages of anti-tumour immune responses. This evidence concerns the gene HAVCR2 and neoplasm.