The PIONEER-HF (Comparison of Sacubitril-Valsartan versus Enalapril on Effect on NT-proBNP in Patients Stabilized from an Acute Heart Failure Episode) clinical trial, an RCT, focused on evaluating the safety and efficacy of initiation of sacubitril-valsartan therapy among patients hospitalized for acute decompensated HF. This evidence concerns the gene NPPB and hydrops fetalis.