PARADIGM-HF: Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure; ACE: angiotensin-converting enzyme; ARB: angiotensin receptor blocker; ACEI: angiotensin-converting enzyme inhibitor; HF: heart failure; MI: myocardial infarction; NT-pro-BNP: N-terminal-pro hormone B-type natriuretic peptide; RCT: randomized control trial. Here, ACE is linked to hydrops fetalis.