Along with revealing the association of pCR with negative HR and positive HER2 status, early tumor stage, no nodal involvement, higher Ki67 index, and molecular subtypes (HER2-enriched and triple-negative), this study also showed pCR to be a positive predictor for OS and DFS, thus strengthening the efficacy of NAC in LABC.The mean age of our study population was 48.6 years (SD±11.0), which is relatively younger than the reported cases worldwide but similar to what has been reported by the Saudi Arabian Cancer Incidence Report and in other Arab countries [12]. Here, ERBB2 is linked to neoplasm.