In addition, macrophage exposure to acrylamide, which is associated with the occurrence and exacerbation of asthma, induces the M2-like phenotype with elevated transforming growth factor (TGF)-β and CCL-2 levels by activating PINK1/Parkin-mediated mitophagy, alleviating ROS-mediated proinflammatory activity [65]. Here, PRKN is linked to asthma.