Several studies have shown that treatment with the lymphopoietin, IL-25, and IL-33, which are secreted from airway epithelial cells in asthma, induces mitochondrial ROS production, and increases the expressions of mitophagy-related proteins PINK1, Parkin, and LC3 in macrophages, suggesting that mitophagy occurs in macrophages, which contributes to M2 macrophage polarization in monocytes [44–46]. The gene discussed is IL33; the disease is asthma.