A recent study has revealed that the lncRNA TRPM2-AS can inhibit autophagy-mediated apoptosis in macrophages by suppressing the TRIM21 (tripartite motif containing 21, an E3 ubiquitin ligase)-induced TRPM2 ubiquitination and further decreasing ROS levels, thus reducing the release of cytokines including IL-1β, IL-4, IL-6, IL-10, TNF-α, and TGF-β in asthma [73]. The gene discussed is IL1B; the disease is asthma.