Neutrophils have been found to recruit macrophages and Tregs cells to HCC by secreting C-C motif chemokine ligand 2 (CCL2) and C-C motif chemokine ligand 17 (CCL17), promoting neovascularization, growth, metastasis, and resistance to sorafenib (Zhou et al., 2016). The gene discussed is CCL2; the disease is hepatocellular carcinoma.