Here using as a model, the CD34+ AML cell line KG1a, a cell line previously described to possess optimum cell migration characteristics both in vitro and in vivo (Dimitroff et al., 2001; Merzaban et al., 2011; AbuSamra et al., 2015; AbuSamra et al., 2017; Ali et al., 2017; AbuZineh et al., 2018; AbuElela et al., 2020; Aleisa et al., 2020; Al Alwan et al., 2021), we investigated the dynamic potential of KG1a-derived exosomes to interact with E-selectin. The gene discussed is CD34; the disease is acute myeloid leukemia.