CTSD and age-related macular degeneration: Similarly, proteomics of exosomes isolated from aqueous humor of AMD patients showed increased abundance of proteins involved in i) the autophagy-lysosomal pathway (e.g., Cathepsin D, CTSD, complement proteins) and ii) epithelial-mesenchymal transition (e.g., Actin Alpha 2, Smooth Muscle, ACTA2, Myosin IF, MYO1F) (Kang et al., 2014).