POU3F2 and melanoma: Similarly, a synthetic peptide derived from the POU domain of BRN2 (R18H) has been demonstrated to induce apoptosis in B16-F10-Nex2 melanoma cells in vitro, while IP administration in C57BL/6 mice resulted in a significant reduction in the formation of metastatic nodules in the lungs, compared to untreated mice (da Cunha et al., 2019).