This ‘switch’ in cadherin expression is driven by downregulation of the EMT transcription factors (EMT-TFs) Snail and Zeb1 (Poser et al., 2001; Kuphal et al., 2004; Zhu L. et al., 2019) and correlates with a low proliferation rate and acquisition of an invasive phenotype in melanoma cells (Kovacs et al., 2016). The gene discussed is SNAI1; the disease is melanoma.