There are several subtypes of cadherins, however type I cadherins are the most relevant to melanoma, and include: epithelial cadherin (E-cadherin, CDH1), present in epithelial cells, melanocytes and keratinocytes; neural cadherin (N-cadherin, CDH2); and placental cadherin (P-cadherin, CDH3) (Yu et al., 2019). Here, CDH2 is linked to melanoma.