AKT1 and cancer: Perifosine (KRX-0401) is a small molecule inhibitor against Akt that has been examined in phase II trials against a range of cancers (NCT00389077, NCT00873457, NCT00455559, NCT00590954, NCT00448721, NCT00498966, NCT00375791, NCT00398879, NCT00053924, NCT00059982).