In vitro studies suggest the potential of utilising STAT3i to target anoikis resistance, with preclinical studies demonstrating that the synthetic inhibitor, AG-490, and the natural compound from black pepper, piplartine (PL), reduce anoikis resistance and induce PARP cleavage, while reducing the migratory potential of melanoma cells (Fofaria and Srivastava, 2014). Here, PARP1 is linked to melanoma.