In particular, Fra-1 (encoded by the gene FOSL1) is important for melanoma progression as its accumulation triggers the transcription factor switch that drives (partial)-EMT, downregulating Zeb2 and SNAI2 and directly upregulating Zeb1 at its promoter (Caramel et al., 2013; Casalino et al., 2022). The gene discussed is ZEB1; the disease is melanoma.