Coinciding with the reduced levels of E-cadherin, melanoma cells gain expression of N-cadherin allowing them to interact with stromal fibroblasts and endothelial cells, promoting migration from the epidermis and dissemination into circulation (Li et al., 2001a; Nguyen and Mège, 2016; Murtas et al., 2017). Here, CDH1 is linked to melanoma.