Inhibition of Timp1, an MMP inhibitor whose overexpression activates PI3K-Akt signalling, induced sensitivity to anoikis in vitro and reduced tumour volume and metastatic colony formation in vivo. Subsequent studies have shown that anoikis resistance induced via the knockdown of α2, α3β1 or α5β1 integrins can be rescued via the specific inhibition of Akt (Kozlova et al., 2019; Kozlova et al., 2020). This evidence concerns the gene AKT1 and neoplasm.