POU3F2 and cancer: Inhibition of BRN2 using B18-94, or inducible CRISPR/Cas9 knockout as a control, was shown to result in the upregulation of pathways for epithelial development and apoptosis, suggesting that direct inhibition of BRN2 may be a feasible way of inducing anoikis in cancer cells that overexpress BRN2.