Diet-induced obesity creates conditions for impaired endothelial nitric oxide synthase activation (31), vascular cell-specific mineralocorticoid and increased aldosterone plasma level, and decreased nitric oxide bioavailability (32) leading to increased vascular permeability and inflammation, leukocyte adhesion, increased vascular constriction, tissue remodeling, and fibrosis (6). This evidence concerns the gene NOS3 and obesity due to melanocortin 4 receptor deficiency.