Diet-induced obesity creates conditions for impaired endothelial nitric oxide synthase activation (31), vascular cell-specific mineralocorticoid and increased aldosterone plasma level, and decreased nitric oxide bioavailability (32) leading to increased vascular permeability and inflammation, leukocyte adhesion, increased vascular constriction, tissue remodeling, and fibrosis (6). The gene discussed is NOS3; the disease is Obesity.