Introducing transgenic mutant α-synuclein into the 3xTransgenic (Tg) AD mouse model, which contains three mutations associated with familial AD (APP Swedish, MAPT P301L, and PSEN1 M146V) and mainly shows progressive Aβ pathogenesis, accelerated Aβ pathology (Clinton et al., 2010). The gene discussed is MAPT; the disease is Alzheimer disease.