MAPT and Alzheimer disease: Currently, many researchers have developed different AD prognostic risk models, including AD prognostic risk model constructed by the psychological theory of amnestic mild cognitive impairment, integrated radiomics model, AD prognostic risk model constructed by combining tau-PET and fMRI, etc. (Ben Bouallegue et al., 2017; Dimitriadis et al., 2018; Zhang et al., 2018; Yi et al., 2020; Shu et al., 2021; Biel et al., 2022).