In view of significant findings we reported about CRP blood levels in our cohort of TRBDD patients (Edberg et al., 2018), we sought to investigate the possible impact of single nucleotide polymorphisms (SNPs) within the CRP gene on CRP blood levels, treatment response as quantitated with the 17-item Hamilton Depression Rating Scale (HAM-D17), and level of stress perception via the Perceived Stress Scale (PSS-14) in our cohort of TRBDD patients receiving ESC and CBX, or ESC and PBO, as previously reported (Halaris et al., 2020). The gene discussed is CRP; the disease is major depressive disorder.