Indeed, animal and clinical studies suggest that obesity disrupts intestinal tight junctions (TJs), allowing for the increased translocation of bacteria and endotoxins (termed bacteremia and endotoxemia, respectively) from the gut into the blood and surrounding tissues that initiates inflammation and insulin resistance [[4], [5], [6], [7], [8]]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.