Accordingly, WG attenuated HFS-induced upregulation of Il6 and Lbp genes, and lessened NF-κBp65 phosphorylation in the visceral adipose tissue to the level of C. In addition, supplemental WG improved metabolic parameters in HFS-fed animals, including fasting blood glucose and insulin resistance marker (HOMA-IR). Here, IL6 is linked to Insulin resistance.