RBM24 and microphthalmia: Forexample, bco1 encodes a key enzyme for vitamin A formationand causes microphthalmia when knocked-down at the larval stage.223Similarly, rbm24a has been found to positively control themRNA stability of sox2 transcripts, with gene knockdownsresulting in a small-eye phenotype.224, , –227 So far, nopathogenic mutations have been successfully detected in human orthologuesBCO1 or RBM24 in microphthalmicpatients, although disease-causing variants of RBM24 areknown to cause cardiomyopathy.