As shown in Figure 1, patients with early-onset T2DM had lower TT (11.93 ± 0.57 vs. 14.04 ± 0.56 nmol/L, p = 0.011), FSH (4.13 ± 0.3 vs. 5.92 ± 0.32 IU/L, p < 0.001), and SHBG (15.03 ± 1.07 vs. 27.29 ± 1.26 nmol/L, p all < 0.05), but higher level of DHEA-S (263.08 ± 12.66 vs. 200.17 ± 8.00 μmol/L, p < 0.001). The gene discussed is SHBG; the disease is type 2 diabetes mellitus.