In the case-control study focused on the effect of vitamin D, although vitamin D levels were not significantly associated with the development of Aromatase inhibitor-induced Arthralgias (AIA), patients with the Fok-I Vitamin D receptor (VDR) variant genotype were more likely to experience a reduction in IL-1β among other inflammatory cytokines (70). This evidence concerns the gene CYP19A1 and Arthralgia.