SMAD4 and breast carcinoma: Also similar to breast cancer, pancreatic cancer has several primary genes related to driving disease, including Kirsten rat sarcoma virus 2(KRAS2), cyclin-dependent kinase inhibitor 2A (p16/CDKN2A), tumor protein 53 (TP53), and mothers against decapentaplegic homolog 4 (SMAD4/DPC4) (10, 11).