In addition to MMP-2 and MMP-9, MMP-1 has also been used as an accurate marker in a three markers scores model, including MMP-1, hepatocyte growth factor, and chemokine ligand 5, to predict axillary lymph node metastasis (LNM) positivity in breast cancer patients (65). This evidence concerns the gene HGF and metastatic malignant neoplasm in the lymph nodes.