CXCL8 and neoplasm: Long-term low levels of plasma IL-8 during chemo-immunotherapy may be prognostic markers of clinical outcomes because elevated levels of circulating IL-8 are associated with poorer outcome (37).Lower IL-8 was significantly associated with overall survival (38).Increases in IL-8 was significantly associated with higher hazard of progression (41).High IL-8 showed poor survival (36).Mice bearing shTAK1 tumors had significantly lower plasma levels of IL-8 and experienced a significant reduction in tumor growth if treated with nal-IRI (44).