Univariate analysis suggested that Age≥65, Albumin ≤ 35, Renal dysfunction, Hypercalcemia, elevated LDH level, ISS III, R-ISS III, Gain 1q21, del 17p, MAF/IGH or MAFB/IGH, ASCT and VD/β-CTX at the time of MM diagnosis were risk factors for PFS in NDMM patients. The gene discussed is ALB; the disease is hypercalcemia disease.