However, the associations found suggest that subsequent obesity development in women with PCOS, with increased IR and inflammation, would likely result in significantly increased C3 and decreased heparin cofactor-II, apoM, alpha-1-antichymotrypsin and alpha-1-antichymotrypsin, thus further increasing their cardiovascular risk. Here, SERPINA3 is linked to obesity due to melanocortin 4 receptor deficiency.