Taken together, the results presented in this paper provide significant evidence that peritumoral AT adipocytes, activated by the presence of tumor cells, secrete factors into the medium that could change their microenvironment by paracrine action on adjacent adipocytes, inducing browning and lipolysis and possibly a “dedifferentiated” given that the long-term treatment led to a decrease in the expression of FABP4, PPARγ, and to a lesser extent CAV-1, while the C/EBPβ-LIP isoform, which is known to act as a trans-dominant repressor, increased in adipocytes undergoing morphological remodeling. The gene discussed is PPARG; the disease is neoplasm.