Our findings also support previous work that reports a significant association between plasma NfL and longitudinal cognitive decline between 6 and 11 years.51,56,57 Previous work has reported associations between plasma GFAP and cognitive functioning in cognitively unimpaired participants,75,76 albeit in the same cohort and with a relatively short follow-up time of 12 months. The gene discussed is GFAP; the disease is Mental deterioration.