MAPT and early-onset autosomal dominant Alzheimer disease: Interestingly, they also identified p-tau 181 in astrocytes and dystrophic neurites around plaques in the temporal cortex, detecting a significant increase of plaques surrounded by astrocytes and neurites containing p-tau 181 in Alzheimer’s disease cases compared to healthy aging controls.7 Despite discrepancy about p-tau presynaptic localization, both studies highlight the possibility of synaptic p-tau species as potential biomarkers, adding important building blocks on our understanding of the relationship between tau and synapse dysfunction.