In this regard, the recent article in Brain Communications by Saunders et al. 7 revealed a significant association of elevated baseline plasma p-tau181, NfL and GFAP, but not Aβ42/40, with greater cognitive decline ∼10 years later, whereas increase of p-tau 181 over time predicted cognitive decline even after correcting for APOE status and an Alzheimer’s disease polygenic risk score. This evidence concerns the gene APOE and Mental deterioration.