Of note, while some transcripts (e.g., COL24A1, COL5A1/A3, COL6A1) were significantly upregulated in both chronic cuprizone mice and specific MS lesion types, others had opposite trend (e.g., COL16A1) or only highly upregulated in the MS white matter but not in mice subjected to chronic cuprizone exposure (e.g., COL1A1/A2, COL8A1/A2). Here, COL8A1 is linked to myeloid sarcoma.