Of note, while some transcripts (e.g., COL24A1, COL5A1/A3, COL6A1) were significantly upregulated in both chronic cuprizone mice and specific MS lesion types, others had opposite trend (e.g., COL16A1) or only highly upregulated in the MS white matter but not in mice subjected to chronic cuprizone exposure (e.g., COL1A1/A2, COL8A1/A2). The gene discussed is COL6A1; the disease is myeloid sarcoma.