Of note, while some transcripts (e.g., COL24A1, COL5A1/A3, COL6A1) were significantly upregulated in both chronic cuprizone mice and specific MS lesion types, others had opposite trend (e.g., COL16A1) or only highly upregulated in the MS white matter but not in mice subjected to chronic cuprizone exposure (e.g., COL1A1/A2, COL8A1/A2). This evidence concerns the gene COL16A1 and myeloid sarcoma.