EGF and fetal growth restriction: The positive control EGF significantly decreased the % of neurons in both groups (Figure 2B, Control: 0.21 ± 0.08%; IUGR: 0.15 ± 0.04%), and significantly increased the metabolic activity in comparison to the solvent control indicating a proliferative effect as expected for this growth factor (Supplementary Figure S1A) proving that the system is flexible and can react to external stimuli known to keep cells in a proliferating instead of in a differentiating status.