Using cohort level data from the ROCKET AF (Rivaroxaban Once daily oral direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in AF) trial to inform a Markov model, the estimated ICER was €8,809 per QALY and the probability of cost-effectiveness was 87% at a threshold of €35,000 per QALY gained (54). This evidence concerns the gene F10 and atrial fibrillation.