For example, lncRNA Safe is enriched in the nuclei of fibroblasts and is elevated in both myocardial infarction and TGF-β-induced cardiac fibrosis, and knockdown of lncRNA Safe significantly inhibits the expression of Sfrp2, its nearby protein-coding gene, by regulating the RNA stability in fibroblasts, thus restraining cardiac fibrosis (22). This evidence concerns the gene TGFB1 and myocardial infarction.