INS and steatosis: In addition, some studies also demonstrated that adiponectin exerted insulin-sensitizing, anti-steatosis, anti-fibrotic, anti-inflammatory and anti-atherosclerosis effects by decreasing gluconeogenesis and de novo lipogenesis, inhibiting ectopic fat deposition, stimulating FFA oxidation, reducing HSC activation and proliferation, and inducing the disorder of anti-inflammatory and pro-inflammatory cytokines (35).