Besides, HSC-derived EVs also contained C-X-C motif ligand 10 (CXCL10), hexokinase 1 (HK1), vascular endothelial growth factor (VEGF), matrix metalloprotein 2 (MMP2) and MMP9, which facilitated tumor growth and transfer, as well as angiogenesis (78). Here, HK1 is linked to neoplasm.