Interestingly, LECT2-deficient mice exhibited increased insulin sensitivity in skeletal muscle rather than in liver or adipose tissue, but muscle insulin sensitivity of LECT2-deficient mice was attenuated by a high-fat diet, indicating that LECT2 may be a therapeutic target for obesity-induced IR (28). This evidence concerns the gene LECT2 and obesity due to melanocortin 4 receptor deficiency.