A large body of literature proposed that ANGPTL3, ANGPTL4, and ANGPTL8 played pivotal roles in the pathogenesis of NAFLD by modulating vitamin D receptor (VDR), IR and lipid metabolism process or its key enzymes, especially lipoprotein lipase (LPL) (21). Here, ANGPTL3 is linked to metabolic dysfunction-associated steatotic liver disease.