Hepatokines are a class of proteins produced by hepatocytes, mainly including fetuin-A, fibroblast growth factor 21 (FGF21), angiopoietin-like proteins (ANGPTLs), leukocyte cell-derived chemotaxin 2 (LECT2), and selenoprotein P (Sep), which have a positive or negative regulatory effect on the pathogenesis of NAFLD by inducing glucose and lipid metabolism, oxidative stress, and systemic inflammation (6). This evidence concerns the gene FGF21 and metabolic dysfunction-associated steatotic liver disease.