It was reported that fetuin-A was involved in the low-grade inflammation response of NAFLD by acting as an endogenous ligand of toll-like receptor 4 (TLR4) and promoting the secretion of proinflammatory cytokines and chemokine in monocytes, macrophages and adipose tissue (9). The gene discussed is TLR4; the disease is metabolic dysfunction-associated steatotic liver disease.