Hepatokines are a class of proteins produced by hepatocytes, mainly including fetuin-A, fibroblast growth factor 21 (FGF21), angiopoietin-like proteins (ANGPTLs), leukocyte cell-derived chemotaxin 2 (LECT2), and selenoprotein P (Sep), which have a positive or negative regulatory effect on the pathogenesis of NAFLD by inducing glucose and lipid metabolism, oxidative stress, and systemic inflammation (6). The gene discussed is SELENOP; the disease is metabolic dysfunction-associated steatotic liver disease.