ANGPTL3, ANGPTL4 and ANGPTL8 are the most extensively studied members of ANGPTLs, and a recent meta-analysis included 13 studies (854 NAFLD patients and 610 controls) found that NAFLD patients had significantly higher circulating ANGPTL8 levels than the healthy controls, while the levels of ANGPTL3 and ANGPTL4 were similar between NAFLD patients and control subjects (20). This evidence concerns the gene ANGPTL4 and metabolic dysfunction-associated steatotic liver disease.