Accumulating evidence delineated that resistin can not only induce hepatocyte steatosis and IR by modulating hepatic lipid metabolism and increasing liver fat content but also stimulate inflammatory cells and HSC to release proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8) and monocyte chemotactic protein 1 (MCP-1), by activating NF-κB signaling pathway (35). The gene discussed is IL6; the disease is steatosis.