According to the preoperative TTE examination, 48 patients were finally divided into group O and 62 into group N. The NYHA class I–II was more prevalent in group N. However, in group O, palpitation and valve disease were found to be more prevalent, ESR and NT-proBNP significantly increased, and myxoma size was more significant. The gene discussed is NPPB; the disease is myxoma.