However, researchers suggested a Beclin1 autophagy-dependent but ATG5 autophagy-independent role in murine chronic myeloid leukemia (CML) model, whereas Beclin1 knockdown, but not Atg5 ablation, leads to a reduced leukemic burden and a significantly higher survival rate of targeted mice [255]. This evidence concerns the gene BECN1 and chronic myelogenous leukemia, BCR-ABL1 positive.