However, researchers suggested a Beclin1 autophagy-dependent but ATG5 autophagy-independent role in murine chronic myeloid leukemia (CML) model, whereas Beclin1 knockdown, but not Atg5 ablation, leads to a reduced leukemic burden and a significantly higher survival rate of targeted mice [255]. Here, ATG5 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.