Goring et al. (2014) completed a metanalysis comparing antidiabetic medications (namely DPP-4 inhibitors, thiazolidinediones, sulfonylureas, and SGLT2-Is) in combination with metformin and found that SGLT2-Is had an equal or decreased risk for hypoglycemia [41]. The gene discussed is SLC5A2; the disease is Hypoglycemia.