Given that UGT1A1 mRNA expression was significantly downregulated in SARS-CoV-2-infected Vero E6 cells and patients with lung cancer have a greater than 7-fold higher risk of SARS-CoV-2 infection (Rolfo et al., 2022), further investigation is required to determine the effect of prescribing UGT1A1 candidate drugs to COVID-19 patients, especially the UGT1A1 poor metabolizers which accounts for about 10% of North Americans (Dean, 2018). This evidence concerns the gene UGT1A1 and lung carcinoma.